GABAergic Neurons from Fatty Liver (CW10130, M, 36, Asian)

Description

Quantity: ~1M viable cells

CIRM Line ID: CW10130

Disease: Fatty Liver

Gender: Male

Sampled age: 36

Race: Asian

Donor data

Demographic (source: CIRM)	Description	FATTY LIVER DISEASE | DEFINITE NASH
	Affected Status	Yes
	Product	iPSC
	Source	PBMC
	Sex	Male
	Age at Sampling	36 YR
	Race	Asian
	Ethnicity	Not Hispanic or Latino
	Publications Cited	0
	dbGap	No
	Biopsy Source	Blood
	Collection	Liver Diseases
	Cell Type	Stem Cell
	Tissue Type	Induced pluripotent stem cell
	Transformant	Episomal
	Species	sapiens
	Common Name	human
	Detailed Clinical Data	false
Clinical data (source: CIRM)	LiverDisordersNASH	LiverDisordersNASH
	Diagnosis	Fatty Liver Disease
	Body_Mass_Index	28.5
	Hypertension	No
	Diabetes	No
	Hyperlipidemia	Yes
	Alcohol_Consumption	None
	HBsAg_negative	Yes
	HCV_antibody_negative	Yes
	ANA_or_IgG_result	normal
	Liver_biopsy_(year)	2014
	Steatosis_score_(0-3)	2
	Ballooning_score_(0-2)	1
	Lobular_inflammation_score_(0-3)	1
	NAS_score_(0-8)	4
	Fibrosis_score_(0-4)	0
	NASH_diagnosis_by_pathologist	definite NASH

• Users do not need any additional license for the use of these differentiated cells even when cells are used for high throughput screening or drug discovery.
• All donor consents include statements on the following:
• Testing the cells’ DNA (this is referred to as the cell’s genetic code or sequence) and making the information known to other researchers
• Changing some of the genetic code or sequence within these cells
• Using cells to test or select drugs to treat disease
• Transplanting cells or resulting products to humans or animals

  Distributing cells widely (nationally and internationally) for research, training or commercial medical product development

• Future research and uses unforeseen at this time
• Donors were screened and negative for HIV, HBV, and HCV. Donors under the age of 18 could opt out of HIV testing; all HCV-positive donors submitted skin punches, not peripheral blood, and were not screened for any infectious agents due to small volume of blood present in punches.
• Human induced pluripotent stem cells were established by non-integrating episomal reprogramming. Reprogramming and quality control were performed by Cellular Dynamics International.