iPSC-derived Dopaminergic Neurons

Human induced pluripotent stem cells (iPSCs) are a powerful tool for studying neuronal activity in vitro. Human iPS cells overcome many of the limitations of other popular models, such as immortalized cell lines and primary mouse neurons, which can be plagued by reproducibility issues and lack of biological relevance. Although human iPS cells have many advantages over existing models, one drawback is that differentiation into the desired cell type is a time and labor intensive process. To address this research bottleneck, Elixirgen Scientific provides a variety of products and services to make research more efficient. Our proprietary technology allows for rapid, reproducible differentiation of human iPSC-derived dopaminergic neurons without sacrificing purity. 

Advantages

  • Fast differentiation and maturation
  • Highly pure population
  • No genetic footprint

Applications

  • Basic research
  • Drug screening
  • Disease modeling

Quick-Neuron™ Dopaminergic Differentiation Kits & Medium

Our Quick-Neuron™ Dopaminergic differentiation kits allow researchers to quickly, easily, and efficiently differentiate their iPS cell line into Dopaminergic neurons. The kits are available in Sendai virus and synthetic mRNA formats, which give comparable efficiencies and do not leave a genetic footprint.

Cat no.Product NameDescription
DA-SeVQuick-Neuron™ Dopaminergic - SeV KitThis kit differentiates human pluripotent stem cells into dopaminergic neurons in 10 days using Sendai Virus.
DA-mRNAQuick-Neuron™ Dopaminergic -mRNA KitThis kit differentiates human pluripotent stem cells into dopaminergic neurons in 10 days using synthetic mRNA.
DA-MMQuick-Neuron™ Dopaminergic - Maintenance MediumThis medium maintains differentiated dopaminergic neurons for up to 2 weeks.

iPSC-derived Dopaminergic Neurons from Healthy and Affected Donors

Elixirgen Scientific’s human iPSC-derived Dopaminergic neurons are created using human iPS cells made available through a license from The California Institute for Regenerative Medicine (CIRM). All of our iPSC-derived Dopaminergic neurons are differentiated using our proprietary technology that utilizes a potent cocktail of key transcription factors to transform iPSCs into high-quality, differentiated Dopaminergic neurons. The CIRM iPS cell repository includes over 1,500 iPS cell lines, so please contact us if you would like Dopaminergic neurons derived from a donor cell line that is not listed in the table below.

Cat No.Product NameDisease Status
DA-SeV-CW50065Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 74 yr)Healthy Control
DA-SeV-CW10149Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (M, 38 yr)Healthy Control
DA-SeV-CW20300Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (M, 10 yr)Healthy Control
DA-SeV-CW50023Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (M, 69 yr)Healthy Control
DA-SeV-CW70067Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 21 yr)Healthy Control
DA-SeV-CW50025Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 68 yr)Alzheimer’s Disease
DA-SeV-CW50113Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (M, 68 yr)Alzheimer’s Disease
DA-SeV-CW50114Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 72 yr)Alzheimer’s Disease
DA-SeV-CW50115Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 67 yr)Alzheimer’s Disease
DA-SeV-CW50137Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 70 yr)Alzheimer’s Disease
DA-SeV-CW50147Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (M, 71 yr)Alzheimer’s Disease
DA-SeV-CW60130Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 6 yr)Epilepsy
DA-SeV-CW60231Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (M, 6 yr)Epilepsy
DA-SeV-CW60236Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 11 yr) Epilepsy
DA-SeV-CW20026Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (M, 10 yr)Autism Spectrum Disorder
DA-SeV-CW20090Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (F, 18 yr)Autism Spectrum Disorder
DA-SeV-CW10130Quick-Neuron™ Dopaminergic - Human iPSC-derived Neurons (M, 36 yr)Fatty Liver Disease

Quick-Neuron™ Dopaminergic Differentiation Service

Elixirgen Scientific provides stem cell differentiation services with the world’s fastest turnaround time. Our differentiation method provides homogenous cell cultures without a genetic footprint. Researchers can simply ship live iPSCs to us and receive differentiating or terminally differentiated Dopaminergic neurons in as little as one week. Each project is unique, so please contact us with your specifications to receive more information or to receive a quote.

Characterization

ipsc-derived dopaminergic neurons

Immunofluorescent staining on day 10 that demonstrates typical neurite outgrowth and homogenous expression of the pan-neuronal marker TUBB3 and dopaminergic neuron-specific marker TH.